Assay Detail
Binding
CHEMBL3387072
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Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.21 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2377791 | — | — | 1 | 7.67 |
| CHEMBL2377787 | — | — | 1 | 7.66 |
| CHEMBL2377790 | — | — | 1 | 7.65 |
| CHEMBL2377794 | — | — | 1 | 7.62 |
| CHEMBL2377788 | — | — | 1 | 7.61 |
| CHEMBL2377789 | — | — | 1 | 7.58 |
| CHEMBL2377795 | — | — | 1 | 7.57 |
| CHEMBL2377793 | — | — | 1 | 7.56 |
| CHEMBL2377771 | — | — | 1 | 7.55 |
| CHEMBL520850 | — | — | 1 | 7.54 |
| CHEMBL2377785 | — | — | 1 | 7.53 |
| CHEMBL312097 | — | — | 1 | 7.52 |
| CHEMBL2377784 | — | — | 1 | 7.51 |
| CHEMBL2377786 | — | — | 1 | 7.51 |
| CHEMBL2377783 | — | — | 1 | 7.47 |
| CHEMBL2377781 | — | — | 1 | 7.45 |
| CHEMBL2377792 | — | — | 1 | 6.90 |
| CHEMBL2377782 | — | — | 1 | 6.83 |
| CHEMBL2377780 | — | — | 1 | 6.75 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL2377776 | — | — | 1 | 6.58 |
| CHEMBL2377773 | — | — | 1 | 6.50 |
| CHEMBL2377772 | — | — | 1 | 6.39 |
| CHEMBL2377778 | — | — | 1 | 6.39 |
| CHEMBL2377775 | — | — | 1 | 6.31 |
| CHEMBL2377774 | — | — | 1 | - |
| CHEMBL2377777 | — | — | 1 | - |
| CHEMBL2377779 | — | — | 1 | - |
| CHEMBL1501298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2377791 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL2377787 | — | Ki | = | 21.8 | nM | 7.66 |
| CHEMBL2377790 | — | Ki | = | 22.2 | nM | 7.65 |
| CHEMBL2377794 | — | Ki | = | 23.9 | nM | 7.62 |
| CHEMBL2377788 | — | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL2377789 | — | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL2377795 | — | Ki | = | 26.8 | nM | 7.57 |
| CHEMBL2377793 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL2377771 | — | Ki | = | 28.3 | nM | 7.55 |
| CHEMBL520850 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL2377785 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL312097 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL2377784 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL2377786 | — | Ki | = | 31.2 | nM | 7.51 |
| CHEMBL2377783 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL2377781 | — | Ki | = | 35.7 | nM | 7.45 |
| CHEMBL2377792 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL2377782 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL2377780 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2377776 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL2377773 | — | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL2377772 | — | Ki | = | 403.0 | nM | 6.39 |
| CHEMBL2377778 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL2377775 | — | Ki | = | 489.0 | nM | 6.31 |
| CHEMBL2377774 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2377777 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL2377779 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1501298 | — | Ki | > | 1000.0 | nM | - |