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Assay Detail

CHEMBL3387279

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Influenza A virus A/WSN/1933(H1N1) neuraminidase H275Y mutant using 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid after 15 mins by fluorescent assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus (A/WSN/1933(H1N1))
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuraminidase (CHEMBL1287610)
Type SINGLE PROTEIN
Organism Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus(strain A/WS/1933 H1N1))

Publication

Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors.
Hong BT, Chen CL, Fang JM, Tsai KC, Wang SY, Huang WI, Cheng YS, Wong CH.
Bioorg Med Chem (2014) 22 : 6647 -6654
PubMed 25456388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.85 7.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3357211 1 7.71
CHEMBL674 OSELTAMIVIR CARBOXYLATE -1.0 1 6.58
CHEMBL3357204 1 6.11
CHEMBL3357212 1 6.08
CHEMBL3357202 1 6.00
CHEMBL3357203 1 5.96
CHEMBL3357213 1 5.96
CHEMBL3357206 1 5.91
CHEMBL3357201 1 5.18
CHEMBL3357205 1 5.16
CHEMBL3357214 1 4.87
CHEMBL3357207 1 4.72
CHEMBL3342331 1 -
CHEMBL3357208 1 -
CHEMBL3357209 1 -
CHEMBL3357210 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3357211 IC50 = 19.5 nM 7.71
CHEMBL674 OSELTAMIVIR CARBOXYLATE IC50 = 260.0 nM 6.58
CHEMBL3357204 IC50 = 781.0 nM 6.11
CHEMBL3357212 IC50 = 832.0 nM 6.08
CHEMBL3357202 IC50 = 1010.0 nM 6.00
CHEMBL3357203 IC50 = 1108.0 nM 5.96
CHEMBL3357213 IC50 = 1108.0 nM 5.96
CHEMBL3357206 IC50 = 1227.0 nM 5.91
CHEMBL3357201 IC50 = 6648.0 nM 5.18
CHEMBL3357205 IC50 = 6946.0 nM 5.16
CHEMBL3357214 IC50 = 13399.0 nM 4.87
CHEMBL3357207 IC50 = 19085.0 nM 4.72
CHEMBL3342331 IC50 - -
CHEMBL3357208 IC50 - -
CHEMBL3357209 IC50 - -
CHEMBL3357210 IC50 - -