Assay Detail
Binding
CHEMBL3387411
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Inhibition of human recombinant AChE after 5 mins by Ellman method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.20 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356536 | — | — | 1 | 9.14 |
| CHEMBL231160 | MEMOQUIN | — | 1 | 8.81 |
| CHEMBL3356532 | — | — | 1 | 8.71 |
| CHEMBL3356951 | — | — | 1 | 8.49 |
| CHEMBL3356533 | — | — | 1 | 8.27 |
| CHEMBL292314 | — | — | 1 | 8.14 |
| CHEMBL3356952 | — | — | 1 | 8.05 |
| CHEMBL3356537 | — | — | 1 | 8.03 |
| CHEMBL3356530 | — | — | 1 | 7.84 |
| CHEMBL3356534 | — | — | 1 | 7.61 |
| CHEMBL3356954 | — | — | 1 | 7.42 |
| CHEMBL3356531 | — | — | 1 | 7.27 |
| CHEMBL3356953 | — | — | 1 | 7.02 |
| CHEMBL3356535 | — | — | 1 | 6.99 |
| CHEMBL3356539 | — | — | 1 | 6.46 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.30 |
| CHEMBL3356538 | — | — | 1 | 6.19 |
| CHEMBL3356950 | — | — | 1 | 6.09 |
| CHEMBL3356540 | — | — | 1 | 5.86 |
| CHEMBL3356528 | — | — | 1 | 5.60 |
| CHEMBL3356529 | — | — | 1 | 5.21 |
| CHEMBL1256415 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356536 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL231160 | MEMOQUIN | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL3356532 | — | IC50 | = | 1.93 | nM | 8.71 |
| CHEMBL3356951 | — | IC50 | = | 3.21 | nM | 8.49 |
| CHEMBL3356533 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL292314 | — | IC50 | = | 7.18 | nM | 8.14 |
| CHEMBL3356952 | — | IC50 | = | 8.94 | nM | 8.05 |
| CHEMBL3356537 | — | IC50 | = | 9.24 | nM | 8.03 |
| CHEMBL3356530 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL3356534 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL3356954 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3356531 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL3356953 | — | IC50 | = | 96.1 | nM | 7.02 |
| CHEMBL3356535 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3356539 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL95 | TACRINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3356538 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL3356950 | — | IC50 | = | 809.0 | nM | 6.09 |
| CHEMBL3356540 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3356528 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL3356529 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL1256415 | — | IC50 | = | 10500.0 | nM | 4.98 |