Assay Detail
Functional
CHEMBL3387540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human GTL16 cells after 72 hrs by CellTitre-Glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GTL 16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.01 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360305 | — | — | 1 | 7.85 |
| CHEMBL3360312 | — | — | 1 | 7.85 |
| CHEMBL3360313 | — | — | 1 | 7.47 |
| CHEMBL3360314 | — | — | 1 | 7.47 |
| CHEMBL3360306 | — | — | 1 | 7.18 |
| CHEMBL3360304 | — | — | 1 | 7.07 |
| CHEMBL3360307 | — | — | 1 | 6.96 |
| CHEMBL3360317 | — | — | 1 | 6.72 |
| CHEMBL3360310 | — | — | 1 | 6.54 |
| CHEMBL3360308 | — | — | 1 | 6.40 |
| CHEMBL3360316 | — | — | 1 | 5.58 |
| CHEMBL3360311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360305 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3360312 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3360313 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3360314 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3360306 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3360304 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3360307 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3360317 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3360310 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3360308 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3360316 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3360311 | — | EC50 | > | 10000.0 | nM | - |