Assay Detail
Binding
CHEMBL3387552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PKC-eta after 60 mins by 33P-ATP incorporation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.19 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214929 | — | — | 1 | 8.30 |
| CHEMBL2147538 | — | — | 1 | 8.05 |
| CHEMBL3338837 | — | — | 1 | 7.12 |
| CHEMBL3338839 | — | — | 1 | 6.29 |
| CHEMBL3338838 | — | — | 1 | 6.18 |
| CHEMBL3338840 | — | — | 1 | - |
| CHEMBL3338841 | — | — | 1 | - |
| CHEMBL3338842 | — | — | 1 | - |
| CHEMBL3338843 | — | — | 1 | - |
| CHEMBL3338844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214929 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2147538 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3338837 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3338839 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL3338838 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3338840 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3338841 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3338842 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3338843 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3338844 | — | IC50 | > | 1000.0 | nM | - |