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Target Snapshot

CHEMBL3616 Target Snapshot

Protein kinase C eta type · SINGLE PROTEIN · Homo sapiens

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1,240Compounds
326Assays
1Approved Drugs
476.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P24723. Use UniProt P24723 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P24723 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein kinase C eta type as ChEMBL target CHEMBL3616, mapped to UniProt P24723. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein kinase C eta type
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3616
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P24723
Protein kinase C eta type
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein kinase C eta type is the right protein anchor across sources, using UniProt P24723 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameProtein kinase C eta type
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP24723
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein kinase C eta type
UniProt AccessionP24723
Component TypeProtein
Sequence Length683 aa

Protein kinase C eta type

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Protein kinase C eta type, mapped to UniProt P24723. Sequence length is 683 aa.

Mapped IDP24723
Review nameProtein kinase C eta type
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
6
Phase III
3
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50291.0
KI54.0
KD131.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2148106 9.96 Ki 0.11 Preclinical
CHEMBL2418196 9.74 Ki 0.18 Preclinical
CHEMBL388978 9.6 IC50 0.251 Preclinical
CHEMBL399981 9.47 Ki 0.34 Preclinical
CHEMBL265998 9.46 Ki 0.35 Preclinical
CHEMBL1256416 9.44 Ki 0.36 Preclinical
CHEMBL2148108 9.35 Ki 0.45 Preclinical
CHEMBL27768 9.35 Kd 0.45 Preclinical
CHEMBL427118 9.22 IC50 0.6 Preclinical
CHEMBL48636 9.22 IC50 0.6 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
18
5.5
35
6.0
47
6.5
51
7.0
49
7.5
57
8.0
26
8.5
20
9.0
4
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
Assay Landscape

Assay Landscape

326
Total Assays
246
Tested Compounds
1
Assay Types
Binding — 326 assays, 246 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 265 229 7.4
assay format 39 2 8.4
cell-based format 22 15 7.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine