Assay Detail
Binding
CHEMBL3387738
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.36 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344468 | — | — | 1 | 6.93 |
| CHEMBL3344466 | — | — | 1 | 6.76 |
| CHEMBL3344469 | — | — | 1 | 6.54 |
| CHEMBL3344467 | — | — | 1 | 6.26 |
| CHEMBL3344470 | — | — | 1 | 6.18 |
| CHEMBL3344465 | — | — | 1 | 6.11 |
| CHEMBL3344458 | — | — | 1 | 6.06 |
| CHEMBL3344456 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344468 | — | Ki | = | 118.7 | nM | 6.93 |
| CHEMBL3344466 | — | Ki | = | 175.32 | nM | 6.76 |
| CHEMBL3344469 | — | Ki | = | 285.33 | nM | 6.54 |
| CHEMBL3344467 | — | Ki | = | 553.1 | nM | 6.26 |
| CHEMBL3344470 | — | Ki | = | 654.64 | nM | 6.18 |
| CHEMBL3344465 | — | Ki | = | 777.79 | nM | 6.11 |
| CHEMBL3344458 | — | Ki | = | 863.8 | nM | 6.06 |
| CHEMBL3344456 | — | Ki | = | 997.7 | nM | 6.00 |