Assay Detail
Binding
CHEMBL3387771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-6-induced STAT3 phosphorylation in human Cal33 cells assessed as nuclear translocation by Western blot analysis
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CAL-33 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.97 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522887 | — | — | 1 | 6.10 |
| CHEMBL3337617 | — | — | 1 | 5.57 |
| CHEMBL3337616 | — | — | 1 | 5.47 |
| CHEMBL1603850 | — | — | 1 | 5.30 |
| CHEMBL1652424 | — | — | 1 | 5.19 |
| CHEMBL3337603 | — | — | 1 | 5.10 |
| CHEMBL3337623 | — | — | 1 | 4.98 |
| CHEMBL3337621 | — | — | 1 | 4.98 |
| CHEMBL3337613 | — | — | 1 | 4.95 |
| CHEMBL3337615 | — | — | 1 | 4.93 |
| CHEMBL3337626 | — | — | 1 | 4.89 |
| CHEMBL3337612 | — | — | 1 | 4.84 |
| CHEMBL1319541 | — | — | 1 | 4.80 |
| CHEMBL3337620 | — | — | 1 | 4.72 |
| CHEMBL1528359 | — | — | 1 | 4.68 |
| CHEMBL3337622 | — | — | 1 | 4.61 |
| CHEMBL1439622 | — | — | 1 | 4.47 |
| CHEMBL3337618 | — | — | 1 | 4.46 |
| CHEMBL3337619 | — | — | 1 | 4.46 |
| CHEMBL3337605 | — | — | 1 | - |
| CHEMBL3337627 | — | — | 1 | - |
| CHEMBL3337625 | — | — | 1 | - |
| CHEMBL3337624 | — | — | 1 | - |
| CHEMBL3337604 | — | — | 1 | - |
| CHEMBL3337457 | — | — | 1 | - |
| CHEMBL3337606 | — | — | 1 | - |
| CHEMBL3337614 | — | — | 1 | - |
| CHEMBL3337607 | — | — | 1 | - |
| CHEMBL3337608 | — | — | 1 | - |
| CHEMBL3337611 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522887 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3337617 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3337616 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1603850 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1652424 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3337603 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3337623 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3337621 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3337613 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3337615 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3337626 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3337612 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1319541 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3337620 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL1528359 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL3337622 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL1439622 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL3337618 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL3337619 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL3337605 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337627 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337625 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337624 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337604 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337457 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337606 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337614 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337607 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337608 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337611 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337610 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337609 | — | IC50 | > | 30000.0 | nM | - |