Assay Detail
Functional
CHEMBL3387779
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Growth inhibition of human CAL33 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-33 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.15 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522887 | — | — | 1 | 5.92 |
| CHEMBL21156 | — | — | 1 | 5.89 |
| CHEMBL3337616 | — | — | 1 | 4.96 |
| CHEMBL1603850 | — | — | 1 | 4.89 |
| CHEMBL3337603 | — | — | 1 | 4.71 |
| CHEMBL1319541 | — | — | 1 | 4.53 |
| CHEMBL3337617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522887 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL21156 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3337616 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1603850 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL3337603 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL1319541 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL3337617 | — | IC50 | > | 50000.0 | nM | - |