Assay Detail

CHEMBL3387838

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to Escherichia coli ribosomes after 2 hrs by fluorescence polarization assay in presence of BODIPY-labeled erythromycin A

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Bacterial 70S ribosome (CHEMBL2363135) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Bacterial 70S ribosome (CHEMBL2363135) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bacterial 70S ribosome

CHEMBL2363135

Anchored from Assay target.

Protein identity Bacterial 70S ribosome

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Subcellular	Ribosome
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Bacterial 70S ribosome (CHEMBL2363135) ↗

Type	PROTEIN NUCLEIC-ACID COMPLEX
Organism	Bacteria

Publication

Desmethyl macrolides: synthesis and evaluation of 4-desmethyl telithromycin.

Glassford I, Lee M, Wagh B, Velvadapu V, Paul T, Sandelin G, DeBrosse C, Klepacki D, Small MC, MacKerell AD, Andrade RB.
ACS Med Chem Lett (2014) 5 : 1021 -1026
PubMed 25221660 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	8.19	8.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3335485	—	—	1	8.19
CHEMBL1136	TELITHROMYCIN	4.0	1	8.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3335485	—	Kd	=	6.4	nM	8.19
CHEMBL1136	TELITHROMYCIN	Kd	=	6.4	nM	8.19