Assay Detail
Functional
CHEMBL3387844
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Antiinflammatory activity against BALB/c mouse splenocytes assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Splenocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.25 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2227733 | TYLOPHORINE SUCCINIC ACID SALT | — | 1 | 7.14 |
| CHEMBL399454 | — | — | 1 | 7.01 |
| CHEMBL2227732 | TYLOPHORINE 2-HYDROXYSUCCINIC ACID SALT | — | 1 | 7.00 |
| CHEMBL2227737 | — | — | 1 | 6.80 |
| CHEMBL2227736 | TYLOPHORINE P-AMINOBENZENESULFONIC ACID SALT | — | 1 | 6.71 |
| CHEMBL2227730 | TYLOPHORINE SALICYLIC ACID SALT | — | 1 | 6.53 |
| CHEMBL2227727 | TYLOPHORINE 2,4,6-TRINITRO PHENOL SALT | — | 1 | 6.51 |
| CHEMBL2227728 | — | — | 1 | 6.48 |
| CHEMBL2227726 | — | — | 1 | 6.47 |
| CHEMBL2227729 | TYLOPHORINE TARTARIC ACID SALT | — | 1 | 6.43 |
| CHEMBL2227724 | TYLOPHORINE HYDROIODIDE | — | 1 | 6.23 |
| CHEMBL2227731 | — | — | 1 | 6.20 |
| CHEMBL2227723 | TYLOPHORINE HYDROBROMIDE | — | 1 | 6.20 |
| CHEMBL2227722 | TYLOPHORINE HYDROCHLORIDE | — | 1 | 6.17 |
| CHEMBL2227725 | TYLOPHORINE BENZOIC ACID SALT | — | 1 | 6.13 |
| CHEMBL1958055 | — | — | 1 | 6.11 |
| CHEMBL493620 | (+/-)-TYLOPHORINE | — | 1 | 6.06 |
| CHEMBL2227735 | TYLOPHORINE 2-HYDROXYPROPANOIC ACID SALT | — | 1 | 6.04 |
| CHEMBL1958056 | — | — | 1 | 6.01 |
| CHEMBL2227734 | TYLOPHORINE P-HYDROXYBENZOIC ACID SALT | — | 1 | 6.01 |
| CHEMBL250426 | (S)-TYLOPHORINE | — | 1 | 5.95 |
| CHEMBL258137 | TYLOPHORINE | — | 1 | 5.92 |
| CHEMBL399965 | — | — | 1 | 5.89 |
| CHEMBL2230073 | — | — | 1 | 4.04 |
| CHEMBL2230071 | — | — | 1 | - |
| CHEMBL2229850 | — | — | 1 | - |
| CHEMBL2229963 | — | — | 1 | - |
| CHEMBL2229861 | — | — | 1 | - |
| CHEMBL2230074 | — | — | 1 | - |
| CHEMBL2230070 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2227733 | TYLOPHORINE SUCCINIC ACID SALT | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL399454 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2227732 | TYLOPHORINE 2-HYDROXYSUCCINIC ACID SALT | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2227737 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2227736 | TYLOPHORINE P-AMINOBENZENESULFONIC ACID SALT | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL2227730 | TYLOPHORINE SALICYLIC ACID SALT | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL2227727 | TYLOPHORINE 2,4,6-TRINITRO PHENOL SALT | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL2227728 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL2227726 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL2227729 | TYLOPHORINE TARTARIC ACID SALT | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL2227724 | TYLOPHORINE HYDROIODIDE | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL2227731 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL2227723 | TYLOPHORINE HYDROBROMIDE | IC50 | = | 628.0 | nM | 6.20 |
| CHEMBL2227722 | TYLOPHORINE HYDROCHLORIDE | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL2227725 | TYLOPHORINE BENZOIC ACID SALT | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL1958055 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL493620 | (+/-)-TYLOPHORINE | IC50 | = | 871.0 | nM | 6.06 |
| CHEMBL2227735 | TYLOPHORINE 2-HYDROXYPROPANOIC ACID SALT | IC50 | = | 918.0 | nM | 6.04 |
| CHEMBL1958056 | — | IC50 | = | 965.0 | nM | 6.01 |
| CHEMBL2227734 | TYLOPHORINE P-HYDROXYBENZOIC ACID SALT | IC50 | = | 972.0 | nM | 6.01 |
| CHEMBL250426 | (S)-TYLOPHORINE | IC50 | = | 1134.0 | nM | 5.95 |
| CHEMBL258137 | TYLOPHORINE | IC50 | = | 1215.0 | nM | 5.92 |
| CHEMBL399965 | — | IC50 | = | 1292.0 | nM | 5.89 |
| CHEMBL2230073 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL2230071 | — | IC50 | = | 231000.0 | nM | - |
| CHEMBL2229850 | — | IC50 | = | 304000.0 | nM | - |
| CHEMBL2229963 | — | IC50 | = | 389000.0 | nM | - |
| CHEMBL2229861 | — | IC50 | = | 363000.0 | nM | - |
| CHEMBL2230074 | — | IC50 | = | 273000.0 | nM | - |
| CHEMBL2230070 | — | IC50 | = | 329000.0 | nM | - |
| CHEMBL2230076 | — | IC50 | = | 317000.0 | nM | - |
| CHEMBL3335486 | — | IC50 | = | 213000.0 | nM | - |
| CHEMBL2230075 | — | IC50 | = | 257000.0 | nM | - |
| CHEMBL2230072 | — | IC50 | = | 275000.0 | nM | - |