Assay Detail
Functional
CHEMBL3387935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction of respiratory exchange ratio in Sprague-Dawley rat assessed as unbound plasma drug concentration measured at 1 mg/kg to 100 mg/kg, po after 120 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.92 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359265 | PF-05175157 | 2.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359265 | PF-05175157 | EC50 | = | 119.0 | nM | 6.92 |