Assay Detail
Functional
CHEMBL3388307
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Cytotoxicity against human Lu cells assessed as reduction in cell growth after 3 days by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lu |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new bioisosteric hemiasterlin analogues with extremely high cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.10 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123 | ELLIPTECINE | — | 1 | 8.74 |
| CHEMBL3338609 | — | — | 1 | 4.59 |
| CHEMBL3338604 | — | — | 1 | 4.49 |
| CHEMBL3338613 | — | — | 1 | 4.37 |
| CHEMBL3338606 | — | — | 1 | 4.26 |
| CHEMBL3338605 | — | — | 1 | 4.17 |
| CHEMBL3338607 | — | — | 1 | - |
| CHEMBL3338608 | — | — | 1 | - |
| CHEMBL3338610 | — | — | 1 | - |
| CHEMBL3338611 | — | — | 1 | - |
| CHEMBL3338612 | — | — | 1 | - |
| CHEMBL3338614 | — | — | 1 | - |
| CHEMBL3338615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123 | ELLIPTECINE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3338609 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL3338604 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL3338613 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL3338606 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL3338605 | — | IC50 | = | 66900.0 | nM | 4.17 |
| CHEMBL3338607 | — | IC50 | > | 269000.0 | nM | - |
| CHEMBL3338608 | — | IC50 | = | 132200.0 | nM | - |
| CHEMBL3338610 | — | IC50 | > | 269000.0 | nM | - |
| CHEMBL3338611 | — | IC50 | > | 269000.0 | nM | - |
| CHEMBL3338612 | — | IC50 | = | 193400.0 | nM | - |
| CHEMBL3338614 | — | IC50 | > | 269000.0 | nM | - |
| CHEMBL3338615 | — | IC50 | = | 205000.0 | nM | - |