Assay Detail
ADMET
CHEMBL3388337
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Inhibition of CYP2C19 (unknown origin) using (S)-mephentoin substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.15 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473326 | — | — | 1 | 5.19 |
| CHEMBL1371684 | — | — | 1 | 5.10 |
| CHEMBL1515648 | — | — | 1 | - |
| CHEMBL514794 | — | — | 1 | - |
| CHEMBL496942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473326 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1371684 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1515648 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL514794 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL496942 | — | IC50 | > | 2500.0 | nM | - |