Assay Detail
Binding
CHEMBL3388366
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Inhibition of trypsin-like activity of human inducible 20S immunoproteasome incubated for 15 mins before fluorogenic substrate addition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Noncovalent fluorescent probes of human immuno- and constitutive proteasomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.43 | 5.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3357584 | — | — | 1 | 5.76 |
| CHEMBL3357585 | — | — | 1 | 5.76 |
| CHEMBL3357582 | — | — | 1 | 5.61 |
| CHEMBL3357583 | — | — | 1 | 5.45 |
| CHEMBL2337849 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3357584 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3357585 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL3357582 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL3357583 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL2337849 | — | IC50 | = | 27700.0 | nM | 4.56 |