Compound Detail
CHEMBL3357582
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C[C@H](NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc21)C(=O)NCc1ccccc1
Basic Information
| ChEMBL ID | CHEMBL3357582 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SOVRGGOLDOIYBC-SNQIAVRVSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1008.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 5.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.83 | 5.485 | 1490.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 1490.0 | nM | 5.83 | Inhibition of chymotrypsin-like activity of human inducible 20S immunoproteasome... | 25333324 |
| Unchecked | IC50 | = | 1930.0 | nM | 5.71 | Inhibition of trypsin-like activity of human constitutive 20S proteasome incubat... | 25333324 |
| Unchecked | IC50 | = | 2430.0 | nM | 5.61 | Inhibition of trypsin-like activity of human inducible 20S immunoproteasome incu... | 25333324 |
| Unchecked | IC50 | = | 2590.0 | nM | 5.59 | Inhibition of chymotrypsin-like activity of human constitutive 20S proteasome in... | 25333324 |
| Unchecked | IC50 | = | 7060.0 | nM | 5.15 | Inhibition of PA activity of human inducible 20S immunoproteasome incubated for ... | 25333324 |
| Unchecked | IC50 | = | 9520.0 | nM | 5.02 | Inhibition of PA activity of human constitutive 20S proteasome incubated for 15 ... | 25333324 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25333324 | 10.1021/jm5011429 | Unchecked | 6 |
Data from ChEMBL 36 via Core Engine