Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3388890

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

New guaiane sesquiterpenes from Artemisia rupestris and their inhibitory effects on nitric oxide production.
Hou J, Dong H, Yan M, Zhu F, Zhang X, Wang H, Ye W, Li P.
Bioorg Med Chem Lett (2014) 24 : 4435 -4438
PubMed 25176187 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.54 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3325481 1 6.75
CHEMBL151 LUTEOLIN 2.0 1 6.68
CHEMBL225304 PIMAGEDINE 2.0 1 6.64
CHEMBL214321 CHRYSOERIOL 1 6.62
CHEMBL3325482 1 6.33
CHEMBL1956398 PECHUELOIC ACID 1 5.52
CHEMBL3325483 1 5.34
CHEMBL3325484 1 5.32
CHEMBL312073 NEVADENSIN 1 5.29
CHEMBL233929 GALUTEOLIN 1 5.08
CHEMBL487018 TILIANINE 1 5.05
CHEMBL3325486 1 5.02
CHEMBL509502 ACACIIN 1 5.00
CHEMBL3325469 1 4.70
CHEMBL3325485 1 4.67
CHEMBL3325487 1 4.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3325481 IC50 = 180.0 nM 6.75
CHEMBL151 LUTEOLIN IC50 = 210.0 nM 6.68
CHEMBL225304 PIMAGEDINE IC50 = 230.0 nM 6.64
CHEMBL214321 CHRYSOERIOL IC50 = 240.0 nM 6.62
CHEMBL3325482 IC50 = 470.0 nM 6.33
CHEMBL1956398 PECHUELOIC ACID IC50 = 3040.0 nM 5.52
CHEMBL3325483 IC50 = 4600.0 nM 5.34
CHEMBL3325484 IC50 = 4750.0 nM 5.32
CHEMBL312073 NEVADENSIN IC50 = 5080.0 nM 5.29
CHEMBL233929 GALUTEOLIN IC50 = 8300.0 nM 5.08
CHEMBL487018 TILIANINE IC50 = 8940.0 nM 5.05
CHEMBL3325486 IC50 = 9510.0 nM 5.02
CHEMBL509502 ACACIIN IC50 = 10020.0 nM 5.00
CHEMBL3325469 IC50 = 20170.0 nM 4.70
CHEMBL3325485 IC50 = 21420.0 nM 4.67
CHEMBL3325487 IC50 = 23260.0 nM 4.63