Assay Detail
Functional
CHEMBL3388995
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Antiviral activity against HCV subtype 1b in human Huh7.5 cells expressing subgenomic HCV replicons and coexpressing luciferase reporter gene
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.35 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344493 | — | — | 1 | 7.55 |
| CHEMBL3344502 | — | — | 1 | 7.54 |
| CHEMBL3344499 | — | — | 1 | 7.54 |
| CHEMBL3344495 | — | — | 1 | 7.48 |
| CHEMBL3344503 | — | — | 1 | 7.44 |
| CHEMBL3344494 | — | — | 1 | 7.44 |
| CHEMBL3344496 | — | — | 1 | 7.43 |
| CHEMBL3344501 | — | — | 1 | 7.40 |
| CHEMBL3344500 | — | — | 1 | 7.38 |
| CHEMBL3344498 | — | — | 1 | 7.38 |
| CHEMBL3344497 | — | — | 1 | 7.36 |
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 7.34 |
| CHEMBL1688529 | NIM811 | 2.0 | 1 | 7.01 |
| CHEMBL1269597 | SCY 635 | 2.0 | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344493 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3344502 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3344499 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3344495 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3344503 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3344494 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3344496 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3344501 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3344500 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3344498 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3344497 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1651956 | ALISPORIVIR | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1688529 | NIM811 | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1269597 | SCY 635 | EC50 | = | 221.0 | nM | 6.66 |