Assay Detail
Functional
CHEMBL3389153
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Inhibition of PGE2 production in LPS-induced mouse RAW264.7 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and PGE₂ production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.22 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7162 | NS-398 | — | 1 | 8.15 |
| CHEMBL3359349 | — | — | 1 | 5.26 |
| CHEMBL3359342 | — | — | 1 | 5.24 |
| CHEMBL3359351 | — | — | 1 | - |
| CHEMBL3359352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7162 | NS-398 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3359349 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL3359342 | — | IC50 | = | 5760.0 | nM | 5.24 |
| CHEMBL3359351 | — | IC50 | - | — | - | |
| CHEMBL3359352 | — | IC50 | - | — | - |