Assay Detail
Functional
CHEMBL3389542
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Antiviral activity against HIV1 NL4-3 expressing reverse transcriptase Y181C mutant infected in human MT4 cells assessed as reduction in virus-induced cell death by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.94 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358170 | — | — | 1 | 9.10 |
| CHEMBL3358176 | — | — | 1 | 8.68 |
| CHEMBL3358161 | — | — | 1 | 8.66 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.22 |
| CHEMBL3358159 | — | — | 1 | 7.80 |
| CHEMBL1766221 | — | — | 1 | 7.75 |
| CHEMBL3358160 | — | — | 1 | 7.18 |
| CHEMBL3358172 | — | — | 1 | 7.17 |
| CHEMBL3358165 | — | — | 1 | 7.06 |
| CHEMBL1766233 | — | — | 1 | 6.97 |
| CHEMBL3358175 | — | — | 1 | 6.89 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.80 |
| CHEMBL3358173 | — | — | 1 | 6.80 |
| CHEMBL3358171 | — | — | 1 | 6.80 |
| CHEMBL3358167 | — | — | 1 | 6.66 |
| CHEMBL3358166 | — | — | 1 | 6.64 |
| CHEMBL3358174 | — | — | 1 | 6.17 |
| CHEMBL3263468 | — | — | 1 | 6.14 |
| CHEMBL3358169 | — | — | 1 | 5.83 |
| CHEMBL3358164 | — | — | 1 | 5.60 |
| CHEMBL79797 | — | — | 1 | 5.29 |
| CHEMBL3358162 | — | — | 1 | 4.37 |
| CHEMBL3358168 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL3358163 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358170 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3358176 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3358161 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3358159 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1766221 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3358160 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3358172 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3358165 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1766233 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3358175 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3358173 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3358171 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3358167 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3358166 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3358174 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3263468 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3358169 | — | EC50 | = | 1474.0 | nM | 5.83 |
| CHEMBL3358164 | — | EC50 | = | 2526.0 | nM | 5.60 |
| CHEMBL79797 | — | EC50 | = | 5174.0 | nM | 5.29 |
| CHEMBL3358162 | — | EC50 | = | 42719.0 | nM | 4.37 |
| CHEMBL3358168 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 3756.0 | nM | - |
| CHEMBL3358163 | — | EC50 | > | 55073.0 | nM | - |