Assay Detail

CHEMBL3389568

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Functional

Antiviral activity against HCV subtype 1a in human Huh7.5 cells expressing subgenomic HCV replicons and coexpressing luciferase reporter gene

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Cell Type	Huh-7
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, Kasprzyk T, Knapp M, Leung K, Li X, Lu P, Mergo W, Miault C, Ng S, Parker D, Peng Y, Roggo S, Rivkin A, Simmons RL, Wang M, Wiedmann B, Weiss AH, Xiao L, Xie L, Xu W, Yifru A, Yang S, Zhou B, Sweeney ZK.
J Med Chem (2014) 57 : 8503 -8516
PubMed 25310383 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	4	6.89	7.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1651956	ALISPORIVIR	3.0	1	7.16
CHEMBL3344501	—	—	1	7.16
CHEMBL1688529	NIM811	2.0	1	6.66
CHEMBL1269597	SCY 635	2.0	1	6.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1651956	ALISPORIVIR	EC50	=	70.0	nM	7.16
CHEMBL3344501	—	EC50	=	70.0	nM	7.16
CHEMBL1688529	NIM811	EC50	=	217.0	nM	6.66
CHEMBL1269597	SCY 635	EC50	=	263.0	nM	6.58