Assay Detail
Functional
CHEMBL3389569
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Antiviral activity against HCV subtype 1b in human Huh7.5 cells expressing subgenomic HCV replicons and coexpressing luciferase reporter gene in presence of 40% human serum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.93 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344501 | — | — | 1 | 7.38 |
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 6.94 |
| CHEMBL1269597 | SCY 635 | 2.0 | 1 | 6.72 |
| CHEMBL1688529 | NIM811 | 2.0 | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344501 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1651956 | ALISPORIVIR | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1269597 | SCY 635 | EC50 | = | 192.0 | nM | 6.72 |
| CHEMBL1688529 | NIM811 | EC50 | = | 210.0 | nM | 6.68 |