Assay Detail
ADMET
CHEMBL3389571
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against PHA-stimulated human PBMC by 5-bromo-2'-deoxyuridine incorporation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.53 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 6.30 |
| CHEMBL1688529 | NIM811 | 2.0 | 1 | 5.62 |
| CHEMBL1269597 | SCY 635 | 2.0 | 1 | 5.33 |
| CHEMBL3344501 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1688529 | NIM811 | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1269597 | SCY 635 | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3344501 | — | IC50 | = | 13200.0 | nM | 4.88 |