Assay Detail
Binding
CHEMBL3389758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MRP1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition measured after 30 mins by fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.06 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260599 | — | — | 1 | 5.55 |
| CHEMBL260505 | — | — | 1 | 5.03 |
| CHEMBL3352978 | — | — | 1 | 5.00 |
| CHEMBL3352989 | — | — | 1 | 4.64 |
| CHEMBL3352975 | — | — | 1 | - |
| CHEMBL3352974 | — | — | 1 | - |
| CHEMBL3352977 | — | — | 1 | - |
| CHEMBL3352979 | — | — | 1 | - |
| CHEMBL3352980 | — | — | 1 | - |
| CHEMBL3352981 | — | — | 1 | - |
| CHEMBL3352982 | — | — | 1 | - |
| CHEMBL3352983 | — | — | 1 | - |
| CHEMBL3352976 | — | — | 1 | - |
| CHEMBL3352985 | — | — | 1 | - |
| CHEMBL3352986 | — | — | 1 | - |
| CHEMBL3352987 | — | — | 1 | - |
| CHEMBL3352973 | — | — | 1 | - |
| CHEMBL3352988 | — | — | 1 | - |
| CHEMBL259582 | — | — | 1 | - |
| CHEMBL260506 | — | — | 1 | - |
| CHEMBL3352984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260599 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL260505 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3352978 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3352989 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3352975 | — | EC50 | - | — | - | |
| CHEMBL3352974 | — | EC50 | - | — | - | |
| CHEMBL3352977 | — | EC50 | - | — | - | |
| CHEMBL3352979 | — | EC50 | - | — | - | |
| CHEMBL3352980 | — | EC50 | - | — | - | |
| CHEMBL3352981 | — | EC50 | - | — | - | |
| CHEMBL3352982 | — | EC50 | - | — | - | |
| CHEMBL3352983 | — | EC50 | - | — | - | |
| CHEMBL3352976 | — | EC50 | - | — | - | |
| CHEMBL3352985 | — | EC50 | - | — | - | |
| CHEMBL3352986 | — | EC50 | - | — | - | |
| CHEMBL3352987 | — | EC50 | - | — | - | |
| CHEMBL3352973 | — | EC50 | - | — | - | |
| CHEMBL3352988 | — | EC50 | - | — | - | |
| CHEMBL259582 | — | EC50 | - | — | - | |
| CHEMBL260506 | — | EC50 | - | — | - | |
| CHEMBL3352984 | — | EC50 | - | — | - |