Assay Detail
Binding
CHEMBL3389934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant HGFA (unknown origin) using Boc-QLR-AMC as substrate by chromogenic proteolytic assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hepatocyte growth factor activator (CHEMBL3351190) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.22 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356596 | — | — | 1 | 7.92 |
| CHEMBL3356606 | — | — | 1 | 7.77 |
| CHEMBL3356597 | — | — | 1 | 7.68 |
| CHEMBL3356603 | — | — | 1 | 7.62 |
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 7.60 |
| CHEMBL3356589 | — | — | 1 | 7.28 |
| CHEMBL3356600 | — | — | 1 | 7.25 |
| CHEMBL3356601 | — | — | 1 | 7.24 |
| CHEMBL3356592 | — | — | 1 | 7.24 |
| CHEMBL3356594 | — | — | 1 | 7.22 |
| CHEMBL3356605 | — | — | 1 | 7.20 |
| CHEMBL3356591 | — | — | 1 | 7.19 |
| CHEMBL3356602 | — | — | 1 | 7.10 |
| CHEMBL3356593 | — | — | 1 | 7.10 |
| CHEMBL3356598 | — | — | 1 | 7.09 |
| CHEMBL3356590 | — | — | 1 | 7.02 |
| CHEMBL3356604 | — | — | 1 | 6.99 |
| CHEMBL3356595 | — | — | 1 | 6.74 |
| CHEMBL191881 | LEUPEPTIN | — | 1 | 6.73 |
| CHEMBL3356599 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356596 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3356606 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3356597 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3356603 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL273264 | NAFAMOSTAT | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3356589 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL3356600 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL3356601 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL3356592 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3356594 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3356605 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL3356591 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL3356602 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL3356593 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL3356598 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL3356590 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL3356604 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL3356595 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL191881 | LEUPEPTIN | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL3356599 | — | Ki | = | 332.0 | nM | 6.48 |