Assay Detail
Binding
CHEMBL3389935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of matriptase (unknown origin) using Boc-QAR-AMC as substrate by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Suppressor of tumorigenicity 14 protein (CHEMBL3018) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 8.20 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 10.70 |
| CHEMBL3356594 | — | — | 1 | 9.49 |
| CHEMBL3356592 | — | — | 1 | 9.16 |
| CHEMBL3356606 | — | — | 1 | 9.08 |
| CHEMBL3356589 | — | — | 1 | 9.04 |
| CHEMBL3356596 | — | — | 1 | 8.96 |
| CHEMBL3356601 | — | — | 1 | 8.52 |
| CHEMBL3356597 | — | — | 1 | 8.26 |
| CHEMBL3356603 | — | — | 1 | 8.24 |
| CHEMBL3356600 | — | — | 1 | 8.07 |
| CHEMBL3356604 | — | — | 1 | 8.06 |
| CHEMBL3356595 | — | — | 1 | 8.04 |
| CHEMBL3356602 | — | — | 1 | 7.92 |
| CHEMBL3356593 | — | — | 1 | 7.82 |
| CHEMBL3356590 | — | — | 1 | 7.66 |
| CHEMBL3356591 | — | — | 1 | 7.50 |
| CHEMBL3356598 | — | — | 1 | 7.24 |
| CHEMBL3356605 | — | — | 1 | 7.16 |
| CHEMBL3356599 | — | — | 1 | 6.98 |
| CHEMBL191881 | LEUPEPTIN | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL3356594 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL3356592 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL3356606 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL3356589 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL3356596 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3356601 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3356597 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL3356603 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL3356600 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL3356604 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3356595 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3356602 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3356593 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3356590 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3356591 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL3356598 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3356605 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL3356599 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL191881 | LEUPEPTIN | Ki | = | 696.0 | nM | 6.16 |