Assay Detail
Binding
CHEMBL3390251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamidoadenosine from human adenosine A2a receptor expressed in HEK293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.44 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3335523 | — | — | 1 | 7.64 |
| CHEMBL331372 | CGS-21680 | — | 1 | 7.16 |
| CHEMBL3335526 | — | — | 1 | 6.57 |
| CHEMBL3335525 | — | — | 1 | 5.48 |
| CHEMBL3335524 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3335523 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL331372 | CGS-21680 | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3335526 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL3335525 | — | Ki | = | 3280.0 | nM | 5.48 |
| CHEMBL3335524 | — | Ki | = | 4360.0 | nM | 5.36 |