Assay Detail
Binding
CHEMBL3390259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]4-[2-[7-amino-2-(2-furyl)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-yl-amino]ethylphenol from wild type human adenosine A2a receptor expressed in HEK293 cells assessed as radioligand Kd compound preincubated for 30 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.39 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3335524 | — | — | 1 | 8.50 |
| CHEMBL331372 | CGS-21680 | — | 1 | 8.36 |
| CHEMBL3335523 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3335524 | — | Kd | = | 3.15 | nM | 8.50 |
| CHEMBL331372 | CGS-21680 | Kd | = | 4.36 | nM | 8.36 |
| CHEMBL3335523 | — | Kd | = | 5.04 | nM | 8.30 |