Assay Detail
Binding
CHEMBL3390431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α<alpha>1 and 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.87 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342867 | — | — | 1 | 8.08 |
| CHEMBL3342853 | — | — | 1 | 7.78 |
| CHEMBL3342856 | — | — | 1 | 7.37 |
| CHEMBL3342860 | — | — | 1 | 7.20 |
| CHEMBL3342859 | — | — | 1 | 7.17 |
| CHEMBL3342871 | — | — | 1 | 7.16 |
| CHEMBL3342868 | — | — | 1 | 7.16 |
| CHEMBL3342874 | — | — | 1 | 7.09 |
| CHEMBL3342872 | — | — | 1 | 7.07 |
| CHEMBL3342866 | — | — | 1 | 7.07 |
| CHEMBL3342870 | — | — | 1 | 6.96 |
| CHEMBL3342862 | — | — | 1 | 6.96 |
| CHEMBL2234448 | — | — | 1 | 6.90 |
| CHEMBL3342876 | — | — | 1 | 6.89 |
| CHEMBL3342852 | — | — | 1 | 6.85 |
| CHEMBL3342869 | — | — | 1 | 6.83 |
| CHEMBL3342857 | — | — | 1 | 6.81 |
| CHEMBL3342863 | — | — | 1 | 6.80 |
| CHEMBL3342861 | — | — | 1 | 6.80 |
| CHEMBL3342875 | — | — | 1 | 6.62 |
| CHEMBL3342855 | — | — | 1 | 6.54 |
| CHEMBL3341769 | — | — | 1 | 6.49 |
| CHEMBL3342873 | — | — | 1 | 6.44 |
| CHEMBL3342854 | — | — | 1 | 6.32 |
| CHEMBL3342865 | — | — | 1 | 6.00 |
| CHEMBL3342864 | — | — | 1 | 6.00 |
| CHEMBL3342858 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342867 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL3342853 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL3342856 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL3342860 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL3342859 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL3342871 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL3342868 | — | Ki | = | 69.18 | nM | 7.16 |
| CHEMBL3342874 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL3342872 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL3342866 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL3342870 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL3342862 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL2234448 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL3342876 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL3342852 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL3342869 | — | Ki | = | 147.91 | nM | 6.83 |
| CHEMBL3342857 | — | Ki | = | 154.88 | nM | 6.81 |
| CHEMBL3342863 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL3342861 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL3342875 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL3342855 | — | Ki | = | 288.4 | nM | 6.54 |
| CHEMBL3341769 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL3342873 | — | Ki | = | 363.08 | nM | 6.44 |
| CHEMBL3342854 | — | Ki | = | 478.63 | nM | 6.32 |
| CHEMBL3342865 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3342864 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3342858 | — | Ki | = | 1000.0 | nM | 6.00 |