Assay Detail
Binding
CHEMBL3390452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 6 mins by spectrophotometric method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.78 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343927 | — | — | 1 | 7.20 |
| CHEMBL3343922 | — | — | 1 | 7.04 |
| CHEMBL3343885 | — | — | 1 | 7.03 |
| CHEMBL3343931 | — | — | 1 | 7.02 |
| CHEMBL3343882 | — | — | 1 | 7.01 |
| CHEMBL3343930 | — | — | 1 | 6.94 |
| CHEMBL3343925 | — | — | 1 | 6.83 |
| CHEMBL3343920 | — | — | 1 | 6.82 |
| CHEMBL3343932 | — | — | 1 | 6.82 |
| CHEMBL3343923 | — | — | 1 | 6.80 |
| CHEMBL3343926 | — | — | 1 | 6.73 |
| CHEMBL3343929 | — | — | 1 | 6.69 |
| CHEMBL3343924 | — | — | 1 | 6.51 |
| CHEMBL3343884 | — | — | 1 | 6.49 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.33 |
| CHEMBL3343928 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343927 | — | IC50 | = | 63.2 | nM | 7.20 |
| CHEMBL3343922 | — | IC50 | = | 91.8 | nM | 7.04 |
| CHEMBL3343885 | — | IC50 | = | 92.6 | nM | 7.03 |
| CHEMBL3343931 | — | IC50 | = | 96.3 | nM | 7.02 |
| CHEMBL3343882 | — | IC50 | = | 98.2 | nM | 7.01 |
| CHEMBL3343930 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3343925 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3343920 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3343932 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3343923 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL3343926 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3343929 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3343924 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL3343884 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL95 | TACRINE | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL3343928 | — | IC50 | = | 526.0 | nM | 6.28 |