Assay Detail
Binding
CHEMBL3390730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes by liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.43 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355781 | — | — | 1 | 10.66 |
| CHEMBL3355780 | — | — | 1 | 10.40 |
| CHEMBL1927270 | — | — | 1 | 9.25 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 9.10 |
| CHEMBL3355779 | — | — | 1 | 8.68 |
| CHEMBL3355778 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355781 | — | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL3355780 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1927270 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3355779 | — | IC50 | = | 2.08 | nM | 8.68 |
| CHEMBL3355778 | — | IC50 | = | 3.2 | nM | 8.49 |