Assay Detail
Functional
CHEMBL3390768
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Antipyroptotic activity in PMA-differentiated and LPS-primed human THP1 cells assessed as decrease in ATP-induced pyroptosis measured as LDH activity after 1 hrs pretreated with 5 mM ATP for 1 hr by colorimetric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.88 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358576 | — | — | 1 | 7.10 |
| CHEMBL3358585 | — | — | 1 | 7.00 |
| CHEMBL4298697 | — | — | 1 | 6.90 |
| CHEMBL2047937 | — | — | 1 | 6.90 |
| CHEMBL3358575 | — | — | 1 | 6.90 |
| CHEMBL3358584 | — | — | 1 | 6.90 |
| CHEMBL3358179 | — | — | 1 | 6.80 |
| CHEMBL3358178 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358576 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3358585 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4298697 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL2047937 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3358575 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3358584 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL3358179 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3358178 | — | EC50 | = | 316.23 | nM | 6.50 |