Assay Detail
Binding
CHEMBL3390777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of caspase 1 (unknown origin) using N-acetyl-Tyr-Val-Ala-Asp-para-nitroanilide substrate assessed as rate of para-nitroanilide release by spectrophotometric assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.00 | 5.02 |
| Kinact | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047937 | — | — | 2 | 5.02 |
| CHEMBL4298697 | — | — | 2 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047937 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL4298697 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL4298697 | — | Kinact | = | 4.0 | /s | - |
| CHEMBL2047937 | — | Kinact | = | 3.2 | /s | - |