Assay Detail

CHEMBL3391006

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Binding

Inhibition of MDMX (unknown origin) by surface plasmon resonance analysis

ChEMBL ↗

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Target

Protein Mdm4 (CHEMBL1255126) ↗

Open DB target context

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Protein Mdm4 (CHEMBL1255126) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Protein Mdm4

CHEMBL1255126

Anchored from Assay target.

Protein identity Protein Mdm4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Protein Mdm4 (CHEMBL1255126) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4)

Macchiarulo A, Giacche N, Carotti A, Moretti F, Pellicciari R
Medchemcomm (2011) 2 : 455 -465
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	8.62	8.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3347580	—	—	1	8.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3347580	—	Kd	=	2.4	nM	8.62