Compound Detail
CHEMBL3347580
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CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O
Basic Information
| ChEMBL ID | CHEMBL3347580 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | MRQDWDIJTZRBOJ-DVDFEGPYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1384.5
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 9.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 CHEMBL5023 | Kd | 9.31 | 9.31 | 0.5 | 1 |
| Protein Mdm4 CHEMBL1255126 | Kd | 8.62 | 8.62 | 2.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | Kd | = | 0.49 | nM | 9.31 | Inhibition of MDM2 (unknown origin) by surface plasmon resonance analysis | - |
| Protein Mdm4 | Kd | = | 2.4 | nM | 8.62 | Inhibition of MDMX (unknown origin) by surface plasmon resonance analysis | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C0MD00238K | E3 ubiquitin-protein ligase Mdm2 | 1 |
| - | 10.1039/C0MD00238K | Protein Mdm4 | 1 |
Data from ChEMBL 36 via Core Engine