Assay Detail
Functional
CHEMBL3391284
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural products targeting telomere maintenance
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.63 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 7.70 |
| CHEMBL297877 | DEOXYHARRINGTONINE | — | 1 | 7.70 |
| CHEMBL511903 | HOMODEOXYHARRINGTONINE | — | 1 | 7.52 |
| CHEMBL3347582 | — | — | 1 | 5.57 |
| CHEMBL3347608 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL297877 | DEOXYHARRINGTONINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL511903 | HOMODEOXYHARRINGTONINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3347582 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL3347608 | — | IC50 | = | 22700.0 | nM | 4.64 |