Assay Detail
Binding
CHEMBL3391289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGTT as primer assessed as polymerization of telomeric repeats to the end of the primers after 2 hrs by Flash-Plate assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural products targeting telomere maintenance
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.40 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222541 | — | — | 1 | 6.70 |
| CHEMBL420982 | — | — | 1 | 5.52 |
| CHEMBL221503 | — | — | 1 | 4.93 |
| CHEMBL75267 | 7,8-DIHYDROXYFLAVONE | — | 1 | 4.44 |
| CHEMBL222211 | — | — | 1 | - |
| CHEMBL301624 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222541 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL420982 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL221503 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL75267 | 7,8-DIHYDROXYFLAVONE | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL222211 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL301624 | — | IC50 | > | 40000.0 | nM | - |