Compound Detail
CHEMBL420982
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Basic Information
| ChEMBL ID | CHEMBL420982 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HJCIUNMVLYBADX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
270.2
MW (Da)
2.58
ALogP
5
HBA
3
HBD
90.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 5.52 | 5.52 | 3000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assay | 15588081 |
| Telomerase reverse transcriptase | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of telomerase extracted from HEK293 cells using 5'-bAATCCGTCGAGCAGAGT... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11170636 | 10.1021/jm0004190 | Staphylococcus aureus | 1 |
| 15588081 | 10.1021/jm040810b | Telomerase reverse transcriptase | 1 |
| 17637507 | 10.1016/j.bmc.2007.06.025 | Serine/threonine-protein kinase pim-1 | 1 |
| 21073191 | 10.1021/jm101206p | BDNF/NT-3 growth factors receptor | 1 |
| - | 10.1039/C0MD00241K | Telomerase reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine