Assay Detail
Binding
CHEMBL3391295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase extracted from human K562 cells preincubated for 10 mins followed by dNTPs and telomerase substrate primer TS-A addition measured after 30 mins by TRAP assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Natural products targeting telomere maintenance
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.90 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8659 | OLEIC ACID | 2.0 | 1 | 5.07 |
| CHEMBL3139878 | — | — | 1 | 4.82 |
| CHEMBL1236642 | VACCENIC ACID | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8659 | OLEIC ACID | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3139878 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1236642 | VACCENIC ACID | IC50 | = | 16000.0 | nM | 4.80 |