Assay Detail
Binding
CHEMBL3391309
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Inhibition of LIMK1 (unknown origin) assessed as remaining ATP level using cofilin-2 protein as substrate measured after 60 mins incubation with enzyme by KinaseGlo assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.41 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3347511 | — | — | 1 | 7.36 |
| CHEMBL3347507 | — | — | 1 | 7.30 |
| CHEMBL3347658 | — | — | 1 | 7.26 |
| CHEMBL3347689 | — | — | 1 | 6.92 |
| CHEMBL3347682 | — | — | 1 | 6.90 |
| CHEMBL3347509 | — | — | 1 | 6.89 |
| CHEMBL3347688 | — | — | 1 | 6.83 |
| CHEMBL3347681 | — | — | 1 | 6.81 |
| CHEMBL3347666 | — | — | 1 | 6.80 |
| CHEMBL3347692 | — | — | 1 | 6.79 |
| CHEMBL3347510 | — | — | 1 | 6.76 |
| CHEMBL3347512 | — | — | 1 | 6.74 |
| CHEMBL3347690 | — | — | 1 | 6.71 |
| CHEMBL3347679 | — | — | 1 | 6.70 |
| CHEMBL3347680 | — | — | 1 | 6.69 |
| CHEMBL3347665 | — | — | 1 | 6.66 |
| CHEMBL3347677 | — | — | 1 | 6.64 |
| CHEMBL3347678 | — | — | 1 | 6.64 |
| CHEMBL3347279 | — | — | 1 | 6.61 |
| CHEMBL3347657 | — | — | 1 | 6.58 |
| CHEMBL1836361 | — | — | 1 | 6.58 |
| CHEMBL3347667 | — | — | 1 | 6.57 |
| CHEMBL1836360 | — | — | 1 | 6.52 |
| CHEMBL3347656 | — | — | 1 | 6.51 |
| CHEMBL3347508 | — | — | 1 | 6.44 |
| CHEMBL3347691 | — | — | 1 | 6.42 |
| CHEMBL3347659 | — | — | 1 | 6.40 |
| CHEMBL3347526 | — | — | 1 | 6.13 |
| CHEMBL3347660 | — | — | 1 | 6.10 |
| CHEMBL3347693 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3347511 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3347507 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3347658 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3347689 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3347682 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL3347509 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3347688 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3347681 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3347666 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL3347692 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL3347510 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL3347512 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL3347690 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL3347679 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL3347680 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3347665 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3347677 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL3347678 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3347279 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL1836361 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3347657 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3347667 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL1836360 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3347656 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3347508 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL3347691 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL3347659 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL3347526 | — | IC50 | = | 732.0 | nM | 6.13 |
| CHEMBL3347660 | — | IC50 | = | 795.0 | nM | 6.10 |
| CHEMBL3347693 | — | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL3347663 | — | IC50 | = | 998.0 | nM | 6.00 |
| CHEMBL1836359 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1836358 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL457313 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL211002 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL207012 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3347664 | — | IC50 | > | 1000.0 | nM | - |