Assay Detail
Binding
CHEMBL3391310
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Inhibition of LIMK1 (unknown origin) assessed as ADP formation using cofilin-2 protein as substrate measured after 60 mins incubation with enzyme by Transcreener assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.87 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2141887 | — | — | 1 | 8.00 |
| CHEMBL2070615 | — | — | 1 | 7.27 |
| CHEMBL3347658 | — | — | 1 | 7.26 |
| CHEMBL3347661 | — | — | 1 | 7.11 |
| CHEMBL3347694 | — | — | 1 | 7.09 |
| CHEMBL3347528 | — | — | 1 | 7.06 |
| CHEMBL3347683 | — | — | 1 | 7.02 |
| CHEMBL3347669 | — | — | 1 | 7.02 |
| CHEMBL3347513 | — | — | 1 | 7.01 |
| CHEMBL3347689 | — | — | 1 | 6.92 |
| CHEMBL3347527 | — | — | 1 | 6.84 |
| CHEMBL3347668 | — | — | 1 | 6.65 |
| CHEMBL3347684 | — | — | 1 | 6.64 |
| CHEMBL3347662 | — | — | 1 | 6.62 |
| CHEMBL1836361 | — | — | 1 | 6.58 |
| CHEMBL3347685 | — | — | 1 | 6.53 |
| CHEMBL3347515 | — | — | 1 | 6.42 |
| CHEMBL3347529 | — | — | 1 | 6.30 |
| CHEMBL3347514 | — | — | 1 | 6.24 |
| CHEMBL3347695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2141887 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2070615 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3347658 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3347661 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3347694 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3347528 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3347683 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3347669 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3347513 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3347689 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3347527 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL3347668 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL3347684 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3347662 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL1836361 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3347685 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL3347515 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL3347529 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL3347514 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL3347695 | — | IC50 | > | 1000.0 | nM | - |