Assay Detail
Binding
CHEMBL3391333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of lithium dodecyl sulphate-stimulated ROS generation preincubated for 15 mins followed by lithium dodecyl sulphate challenge by cell-free assay in presence of NADPH
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS 22 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3347551 | — | — | 1 | 7.52 |
| CHEMBL3347550 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3347551 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3347550 | — | IC50 | = | 30.0 | nM | 7.52 |