Assay Detail
Functional
CHEMBL3395327
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.56 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393209 | — | — | 1 | 4.87 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 4.73 |
| CHEMBL334918 | MAACKIAIN | — | 1 | 4.57 |
| CHEMBL3314594 | — | — | 1 | 4.55 |
| CHEMBL3393208 | — | — | 1 | 4.48 |
| CHEMBL513023 | MEDIORESINOL | — | 1 | 4.39 |
| CHEMBL267963 | (+)-PINORESINOL | — | 1 | 4.35 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
| CHEMBL241608 | CALYCOSIN | — | 1 | - |
| CHEMBL294878 | — | — | 1 | - |
| CHEMBL361362 | SYRINGARESINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393209 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL334918 | MAACKIAIN | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3314594 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL3393208 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL513023 | MEDIORESINOL | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL267963 | (+)-PINORESINOL | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL44 | GENISTEIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL241608 | CALYCOSIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL294878 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL361362 | SYRINGARESINOL | IC50 | > | 50000.0 | nM | - |