Assay Detail
Binding
CHEMBL3395429
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Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupling based spectrophotometry
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.78 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393956 | — | — | 1 | 7.00 |
| CHEMBL3393955 | — | — | 1 | 6.35 |
| CHEMBL3393950 | — | — | 1 | 6.16 |
| CHEMBL3393951 | — | — | 1 | 6.16 |
| CHEMBL3393934 | — | — | 1 | 6.06 |
| CHEMBL3393947 | — | — | 1 | 5.96 |
| CHEMBL3393936 | — | — | 1 | 5.89 |
| CHEMBL3393952 | — | — | 1 | 5.88 |
| CHEMBL3393941 | — | — | 1 | 5.85 |
| CHEMBL3393957 | — | — | 1 | 5.80 |
| CHEMBL3393953 | — | — | 1 | 5.77 |
| CHEMBL3393946 | — | — | 1 | 5.75 |
| CHEMBL3393948 | — | — | 1 | 5.70 |
| CHEMBL31344 | — | — | 1 | 5.70 |
| CHEMBL3393935 | — | — | 1 | 5.68 |
| CHEMBL3393944 | — | — | 1 | 5.62 |
| CHEMBL3393942 | — | — | 1 | 5.62 |
| CHEMBL3393949 | — | — | 1 | 5.56 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 5.50 |
| CHEMBL3393933 | — | — | 1 | 5.29 |
| CHEMBL3393943 | — | — | 1 | 5.28 |
| CHEMBL3393945 | — | — | 1 | 5.28 |
| CHEMBL3393954 | — | — | 1 | 5.19 |
| CHEMBL3393940 | — | — | 1 | - |
| CHEMBL3393939 | — | — | 1 | - |
| CHEMBL3393938 | — | — | 1 | - |
| CHEMBL3393937 | — | — | 1 | - |
| CHEMBL50753 | — | — | 1 | - |
| CHEMBL1950316 | — | — | 1 | - |
| CHEMBL51414 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393956 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3393955 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3393950 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3393951 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3393934 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3393947 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3393936 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL3393952 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL3393941 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3393957 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3393953 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3393946 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3393948 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL31344 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3393935 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3393944 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3393942 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3393949 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL752 | ADENOSINE PHOSPHATE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3393933 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL3393943 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL3393945 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL3393954 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL3393940 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3393939 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3393938 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3393937 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL50753 | — | IC50 | - | — | - | |
| CHEMBL1950316 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL51414 | — | IC50 | - | — | - |