Assay Detail
Binding
CHEMBL3395585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DLK (unknown origin)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 12 (CHEMBL1908389) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.69 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3393337 | — | — | 1 | 9.70 |
| CHEMBL3393334 | — | — | 1 | 9.15 |
| CHEMBL3393329 | — | — | 1 | 9.05 |
| CHEMBL3393340 | — | — | 1 | 9.00 |
| CHEMBL3393327 | — | — | 1 | 9.00 |
| CHEMBL3393322 | — | — | 1 | 8.70 |
| CHEMBL3393314 | — | — | 1 | 8.40 |
| CHEMBL3393332 | — | — | 1 | 8.30 |
| CHEMBL3393330 | — | — | 1 | 8.30 |
| CHEMBL3393321 | — | — | 1 | 8.15 |
| CHEMBL3393320 | — | — | 1 | 8.15 |
| CHEMBL3393336 | — | — | 1 | 8.10 |
| CHEMBL3393335 | — | — | 1 | 8.10 |
| CHEMBL3393331 | — | — | 1 | 7.85 |
| CHEMBL3393339 | — | — | 1 | 7.75 |
| CHEMBL3393315 | — | — | 1 | 7.75 |
| CHEMBL3393312 | — | — | 1 | 7.62 |
| CHEMBL3393328 | — | — | 1 | 7.60 |
| CHEMBL3393324 | — | — | 1 | 7.48 |
| CHEMBL3393308 | — | — | 1 | 7.46 |
| CHEMBL3393323 | — | — | 1 | 7.39 |
| CHEMBL3393318 | — | — | 1 | 7.24 |
| CHEMBL3393310 | — | — | 1 | 7.07 |
| CHEMBL3393317 | — | — | 1 | 7.05 |
| CHEMBL3393338 | — | — | 1 | 7.03 |
| CHEMBL3393325 | — | — | 1 | 6.78 |
| CHEMBL3393313 | — | — | 1 | 6.71 |
| CHEMBL3393309 | — | — | 1 | 6.40 |
| CHEMBL3393326 | — | — | 1 | 6.37 |
| CHEMBL3393311 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3393337 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3393334 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3393329 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL3393340 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3393327 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3393322 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3393314 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3393332 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3393330 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3393321 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL3393320 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL3393336 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3393335 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL3393331 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3393315 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3393339 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3393312 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3393328 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3393324 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3393308 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3393323 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL3393318 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL3393310 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL3393317 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3393338 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3393325 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL3393313 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL3393309 | — | Ki | = | 401.0 | nM | 6.40 |
| CHEMBL3393326 | — | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL3393311 | — | Ki | = | 691.0 | nM | 6.16 |
| CHEMBL3393319 | — | Ki | = | 725.0 | nM | 6.14 |
| CHEMBL3393316 | — | Ki | = | 942.0 | nM | 6.03 |
| CHEMBL3393333 | — | Ki | < | 0.5 | nM | - |