Assay Detail
Binding
CHEMBL3395623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights on the role of boron containing moieties in the design of new potent and efficient agonists targeting the β2 adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.30 | 7.75 |
| EC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.75 |
| CHEMBL3393402 | — | — | 2 | 7.55 |
| CHEMBL714 | ALBUTEROL | 4.0 | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | Kd | = | 17.78 | nM | 7.75 |
| CHEMBL3393402 | — | Kd | = | 28.18 | nM | 7.55 |
| CHEMBL714 | ALBUTEROL | Kd | = | 245.47 | nM | 6.61 |
| CHEMBL3393402 | — | EC50 | <= | 280.0 | nM | - |