Assay Detail
Binding
CHEMBL3395778
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Inhibition of p38alpha (unknown origin) assessed as phosphorylation of ATF-2 by ELISA
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.64 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394106 | — | — | 1 | 7.52 |
| CHEMBL3394121 | — | — | 1 | 7.47 |
| CHEMBL3394097 | — | — | 1 | 7.44 |
| CHEMBL3394125 | — | — | 1 | 7.44 |
| CHEMBL3394107 | — | — | 1 | 7.41 |
| CHEMBL3394102 | — | — | 1 | 6.91 |
| CHEMBL3394120 | — | — | 1 | 6.89 |
| CHEMBL3394112 | — | — | 1 | 6.87 |
| CHEMBL3394095 | — | — | 1 | 6.85 |
| CHEMBL3394126 | — | — | 1 | 6.84 |
| CHEMBL3394122 | — | — | 1 | 6.84 |
| CHEMBL3394119 | — | — | 1 | 6.82 |
| CHEMBL3394104 | — | — | 1 | 6.79 |
| CHEMBL3394105 | — | — | 1 | 6.78 |
| CHEMBL3394124 | — | — | 1 | 6.74 |
| CHEMBL3394100 | — | — | 1 | 6.72 |
| CHEMBL3394103 | — | — | 1 | 6.68 |
| CHEMBL3394117 | — | — | 1 | 6.68 |
| CHEMBL3394108 | — | — | 1 | 6.65 |
| CHEMBL3394098 | — | — | 1 | 6.61 |
| CHEMBL3394094 | — | — | 1 | 6.53 |
| CHEMBL3394101 | — | — | 1 | 6.47 |
| CHEMBL3394118 | — | — | 1 | 6.45 |
| CHEMBL3394123 | — | — | 1 | 6.45 |
| CHEMBL3394110 | — | — | 1 | 6.38 |
| CHEMBL3394114 | — | — | 1 | 6.35 |
| CHEMBL3394113 | — | — | 1 | 6.21 |
| CHEMBL3394093 | — | — | 1 | 6.19 |
| CHEMBL3394116 | — | — | 1 | 6.18 |
| CHEMBL3394109 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394106 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3394121 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3394097 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3394125 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3394107 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3394102 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL3394120 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL3394112 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL3394095 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3394126 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL3394122 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL3394119 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3394104 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3394105 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL3394124 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL3394100 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL3394117 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3394103 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL3394108 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL3394098 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL3394094 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL3394101 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL3394118 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL3394123 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL3394110 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL3394114 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL3394113 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL3394093 | — | IC50 | = | 642.0 | nM | 6.19 |
| CHEMBL3394116 | — | IC50 | = | 655.0 | nM | 6.18 |
| CHEMBL3394109 | — | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL3394111 | — | IC50 | = | 764.0 | nM | 6.12 |
| CHEMBL3394096 | — | IC50 | = | 1666.0 | nM | 5.78 |
| CHEMBL3394099 | — | IC50 | = | 1699.0 | nM | 5.77 |
| CHEMBL3394115 | — | IC50 | = | 2184.0 | nM | 5.66 |