Assay Detail
Binding
CHEMBL3395843
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Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence intensity after 30 mins by ALPHA assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel Asf1-H3/H4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.70 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199405 | — | — | 1 | 6.22 |
| CHEMBL3394920 | — | — | 1 | 5.52 |
| CHEMBL3394913 | — | — | 1 | 5.00 |
| CHEMBL3394915 | — | — | 1 | 4.96 |
| CHEMBL3394894 | — | — | 1 | 4.92 |
| CHEMBL3394895 | — | — | 1 | 4.85 |
| CHEMBL3394904 | — | — | 1 | 4.82 |
| CHEMBL3394905 | — | — | 1 | 4.82 |
| CHEMBL3394912 | — | — | 1 | 4.60 |
| CHEMBL3394906 | — | — | 1 | 4.58 |
| CHEMBL3394896 | — | — | 1 | 4.57 |
| CHEMBL3394902 | — | — | 1 | 4.52 |
| CHEMBL3394911 | — | — | 1 | 4.52 |
| CHEMBL3394891 | — | — | 1 | 4.50 |
| CHEMBL3394903 | — | — | 1 | 4.35 |
| CHEMBL3394908 | — | — | 1 | 4.32 |
| CHEMBL3394910 | — | — | 1 | 4.30 |
| CHEMBL3394919 | — | — | 1 | 4.26 |
| CHEMBL3394901 | — | — | 1 | 4.22 |
| CHEMBL3394918 | — | — | 1 | 4.07 |
| CHEMBL3394900 | — | — | 1 | - |
| CHEMBL3394924 | — | — | 1 | - |
| CHEMBL3394892 | — | — | 1 | - |
| CHEMBL3394893 | — | — | 1 | - |
| CHEMBL3394923 | — | — | 1 | - |
| CHEMBL3394922 | — | — | 1 | - |
| CHEMBL3394921 | — | — | 1 | - |
| CHEMBL3394897 | — | — | 1 | - |
| CHEMBL3394898 | — | — | 1 | - |
| CHEMBL3394899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199405 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3394920 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3394913 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3394915 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3394894 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3394895 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3394904 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3394905 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3394912 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3394906 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3394896 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3394902 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3394911 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3394891 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3394903 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3394908 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3394910 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3394919 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3394901 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL3394918 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL3394897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394909 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394925 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL3394907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394914 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394916 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394917 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394898 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394921 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394922 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394923 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394893 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394892 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394924 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3394900 | — | IC50 | > | 100000.0 | nM | - |