Compound Detail
CHEMBL3394913
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Basic Information
| ChEMBL ID | CHEMBL3394913 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FIDCSAAIHNKBJM-ZTKZIYFRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
486.6
MW (Da)
4.19
ALogP
6
HBA
2
HBD
92.3
PSA (Ų)
0.33
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone chaperone ASF1A CHEMBL3392950 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone chaperone ASF1A | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of His-tagged human Asf1a binding with H3/H4 assessed as fluorescence... | 25582598 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25582598 | 10.1016/j.bmcl.2014.11.067 | Histone chaperone ASF1A | 1 |
Data from ChEMBL 36 via Core Engine