Assay Detail
Binding
CHEMBL3395875
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Inhibition of PI3K p110alpha (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.30 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL510164 | — | — | 1 | 8.70 |
| CHEMBL589258 | — | — | 1 | 8.70 |
| CHEMBL1921986 | — | — | 1 | 8.32 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 7.80 |
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 7.80 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.26 |
| CHEMBL3393502 | — | — | 1 | 5.89 |
| CHEMBL104468 | — | — | 1 | 4.89 |
| CHEMBL1972466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL510164 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL589258 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1921986 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3393066 | VS-5584 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL98350 | LY-294002 | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3393502 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL104468 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1972466 | — | IC50 | > | 1000.0 | nM | - |